Sustained Delivery of Molecular Hydrogen for Multiple Applications


Molecular hydrogen is the most effective antioxidant currently known, and this makes it a centerpiece of dynamic balance. Oxidative stress destroys physiological harmony. It is a major cause of inflammation and is implicated in a host of diseases, as well as the general physical and mental deterioration caused by aging.


H2 is the only molecule shown to deliver numerous health benefits through an antioxidant effect when consumed. Most if not all clinical trials of many other popular antioxidants yield disappointing results.  


Antioxidants neutralize free radical reactive oxygen species (ROS). What can be forgotten is that free radicals aren’t universally bad. Many play important signaling functions in the body. So it matters which are attacked by an antioxidant. This again is a question of balance.


Molecular hydrogen appears to be highly selective in its antioxidant effects. It primarily neutralizes hydroxyl radical and peroxynitrite, the most toxic of the ROS. Free radicals that play a benign physiological role are left untouched by H2.

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Molecular hydrogen is highly diffusible. In fact, H2 spreads throughout the entire body within 10 minutes of ingestion. Because of the molecule’s neutrality and small size, it can rapidly penetrate biomembranes, enter the mitochondria, and cross the blood-brain barrier. In fact, H2 can reach every component of every cell in the body. This means it delivers its therapeutic benefits to sites that are otherwise difficult or impossible to reach.


Apart from being flammable, H2 is completely safe and natural to the human body.


Unlike the other therapeutic gasses, which provide both benefits and hazards, H2 only causes reactions in the presence of a catalyst, and these reactions appear to occur only when needed to counteract some imbalance or pathology. In fact, H2 counterbalances the potentially harmful consequences of other therapeutic gases such as O2 and NO.


Because of its selective activity, it is effectively impossible to consume too much hydrogen: the lungs expel any unrequired excess.


Molecular hydrogen when delivered in water has been granted a GRAS (generally recognized as safe) designation by the FDA.


Molecular hydrogen is one of several gasses naturally found in the human body that can have therapeutic applications, including oxygen, nitric oxide, hydrogen sulfide, carbon monoxide and carbon dioxide.


H2 is a neutral, taste-free, inert gas that is non-polar, non-radical and non-reactive. From an evolutionary perspective, it appears that both plants and animals have developed symbiotic relationships with hydrogen-producing bacteria, and H2 may have played a significant role in the origin of life and the evolution of eukaryotes.


H2 is not known to specifically interact with any particular receptors and probably has no binding sites in the body. Nevertheless, over 200 biomolecules can be altered by H2 administration, including over 1,000 gene expressions.


The method by which H2 produces its health benefits is still being researched, though it is known to modulate cellular signal transduction and protein phosphorylation. 


Scientific research of molecular hydrogen is still in its infancy, but the community of scientists engaged in this field is growing rapidly, with increasing studies on the activity of H2 in humans, animals, tissues and plants. Serious biomedical research into molecular hydrogen began in 1975 and expanded more rapidly from 2007 when the therapeutic inhalation of H2 was first studied. There are by now over 1000 peer-reviewed studies of H2, of which more than 100 are human studies.


New studies of molecular hydrogen are appearing with increasing rapidity. Meanwhile, there’s increasing interest in translating this burgeoning science into clinical tools.



As a therapeutic agent, molecular hydrogen is usually delivered by means of inhalation, intravenous injection, or tablets dissolved in water. All these methodologies present challenges. Inhalation and injection are cumbersome, and all three fail to hold the hydrogen efficiently: much is rapidly lost. This means administration of H2 by these methods must be frequently repeated.


Another challenge of delivering molecular hydrogen to the body is controlling and measuring the dosage of H2 administered. When H2 is delivered through inhalation, treated water, or by injection, it is effectively impossible to know how much H2 has entered the system, because much of the gas quickly escapes.




NutraGenom has patented a proprietary biotechnology platform to sequester and stabilize H2. This platform enables oral delivery of H2 in quantities hundreds of times higher than other common methods.


Known as Zydrogen   Molecular Hydrogen Technology (MHT), this new platform binds H2 to a natural, ingestible biopolymer with magnesium metal powder. When consumed, the molecular hydrogen is continuously released in the gut and spreads throughout the body. The release continues for up to 24 hours, providing the entire system with the anti-inflammatory and antioxidant benefits of H2.


Zydrogen   MHT provides a far more controlled delivery mechanism, because the hydrogen is sequestered in the body through its binding to an ingestible polymer. This allows people to know how much H2 they are getting over a given period of time.





NutraGenom’s patented Zydrogen   MHT platform enables a wider range of applications than any existing delivery method for molecular hydrogen. Our R&D department is currently working on these specific solutions:

  • Topical application for dermatological products

  • Anti-aging dietary supplements

  • The addition of H2 to functional foods

  • An ingestible medical device for weight management

  • A unique medical device application

  • Drug delivery technologies